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Chronic Fatigue Virus Dismissed

Posted: December 22nd, 2011 | Author: | Filed under: Cankler Science News, Medicated | Tags: , , , , , , , , | Comments Off

Chronic Fatigue Virus XMRV DismissedThe theory that chronic fatigue syndrome is caused by a virus has been killed off. It is just two years since researchers gave hope to sufferers that a cure may be on the horizon. In late December 2011 two of the global giants of science publishing from the United States, Science and Proceedings of the National Academy of Science, withdrew published papers which claimed sufferers carried a virus. Over the past three decades chronic fatigue syndrome (CFS), or myalgic encephalomyelitis (ME), has lost the dismissive tag of “yuppie disease” and is no longer thought to be only a psychiatric condition. It may affect 17 million people around the world, but there is no agreed cause or cure. Yet the studies caused blood banks, including the Red Cross, to ban blood donations from people who had suffered CFS. A medical science professor at the University of New South Wales, Andrew Lloyd, says fundamental steps to good science and clinical care were by-passed. He says it is understandable that CFS sufferers jump on any new discovery.

The prominent journal Science has retracted a 2009 report linking a mouse retrovirus to chronic fatigue syndrome after it was disproved by researchers earlier this year. The 2009 study led by Dr Judy Mikovits, the director of the Whittemore Peterson Institute, found that the retrovirus XMRV was frequently present in the blood of chronic fatigue sufferers, without establishing a causal link. The Journal Science said it had “lost confidence in the report and the validity of its conclusions” after multiple laboratories, including those of the original authors, failed to detect the virus in chronic fatigue patients.

The journal said most of the authors had agreed in principle to retract the report but were unable to agree on the precise wording. ”It is Science’s opinion that a retraction signed by all the authors is unlikely to be forthcoming. We are therefore editorially retracting the report. ”We regret the time and resources devoted to unsuccessful attempts to replicate these results,” it added.The study had been hailed as a breakthrough for the estimated one to four million Americans who suffer from the elusive but debilitating illness, and led to many being treated with antiretroviral drugs used against HIV/AIDS. Read the full article »»»»


Journal Retracts Paper Linking Mouse Virus With Chronic Fatigue

Posted: December 22nd, 2011 | Author: | Filed under: Medicated | Tags: , , , , , , , , | Comments Off

Journal Retracts Paper Linking Mouse Virus With CFSMedPage Today is reporting that a scientific paper that reported a strong association between a mouse retrovirus called XMRV and chronic fatigue syndrome – CFS – has been formally retracted.

Science posted a statement early Thursday from editor-in-chief Bruce Alberts, PhD, indicating that the journal had “lost confidence” in the first article to link XMRV to CFS, published in 2009 by Vincent Lombardi, PhD, and other researchers at the Whittemore Peterson Institute in Reno, Nevada.

“We note that the majority of the authors have agreed in principle to retract the report but they have been unable to agree on the wording of their statement,” Alberts wrote.

“It is Science’s opinion that a retraction signed by all the authors is unlikely to be forthcoming. We are therefore editorially retracting the report. We regret the time and resources that the scientific community has devoted to unsuccessful attempts to replicate these results.”

Alberts had been pressing the authors to retract the paper since May, when Science published an “expression of concern” about the 2009 paper’s validity.

In justifying his decision to retract the paper now without the authors’ full consent, Alberts cited the inability of other laboratories to reproduce the findings. In what was probably the fatal blow to the XMRV-CFS theory, tests on blinded clinical samples sent to nine research groups failed to consistently show the virus in patients’ blood  :: Read the full MedPage article »»»»

RELATED:

US Researchers Find ANOTHER Mouse Virus Prevalent in Chronic Fatigue Patients

NO LINK Between Mouse Virus and Chronic Fatigue


NO LINK Between Mouse Virus and Chronic Fatigue

Posted: December 21st, 2010 | Author: | Filed under: Medicated | Tags: , , , , , , , , | Comments Off

NO LINK Between Mouse Virus & CFSBloomberg is reporting that A mouse virus linked to chronic fatigue syndrome may not be the cause of the disease, according to four studies that cast doubt on the basis of a U.S. move to ban sufferers of the energy-sapping illness from donating blood.

Researchers from the U.S., U.K. and Japan found that previous research linking the virus, XMRV, to chronic fatigue and prostate cancer may have used contaminated specimens and chemicals that led the scientists involved to draw the wrong conclusions. The studies were published yesterday in the journal Retrovirology.

The American Red Cross, the largest U.S. supplier of blood products, said Dec. 3 it would no longer allow donors with chronic fatigue syndrome, based on results of a study published last year that was the first to link the condition to XMRV. The U.S. Food and Drug Administration is considering banning blood donors with the illness.

“Our conclusion is quite simple: XMRV is not the cause of chronic fatigue syndrome,” Greg Towers, who led one of the four new studies at University College London, said in a statement. “We are not saying chronic fatigue syndrome does not have a virus cause — we cannot answer that yet – but we know it is not this virus,” Towers said.

The U.K., Australia, Canada and New Zealand have decided to defer blood donations from people with chronic fatigue syndrome, according to the FDA  :: Read the full Bloomberg article »»»»

RELATED:

US Researchers Find ANOTHER Mouse Virus Prevalent in Chronic Fatigue Patients


US Researchers Find ANOTHER Mouse Virus Prevalent in Chronic Fatigue Patients

Posted: August 14th, 2010 | Author: | Filed under: Medicated | Tags: , , , , , , , , | Comments Off

US Researchers Find XMRV Prevalence in CFS PatientsResearchers in the US  have made another tentative link between a virus common in mice  - MLVsMurine Leukemia Viruses - and CFS, Chronic Fatigue SyndromeHowever the researchers say that their findings still don’t prove that any virus causes CFS symptoms.

CFS is generally defined by persistent fatigue accompanied by other specific symptoms for a minimum of six months in adults and 3 months in children or adolescents, CFS is not due to ongoing exertion, not substantially relieved by rest, nor does it seem to be caused by any other medical condition.

The research team lead by Dr Harvey Alter, of the Us Department of Health & Human Services’ National Institutes of Health, reported their findings in  Proceedings of the National Academy of Sciences.

The researchers found evidence that murine leukemia virus – a cancer causing virus in mice – in 86% of chronic fatigue patients they tested, but in fewer than 7% of healthy blood donors.

Dr Alter and his colleagues said that much more research is needed to determine how common the virus is in the general population and whether it might be causing disease, or whether it is simply an innocent bystander :: Read the full article »»»»